Apalutamide Impurity 72 CAS 1950587-19-5
| CAS No. | 1950587-19-5 |
| Molecular Formula | C21H14F4N4O3S |
| Molecular Weight | 478.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Apalutamide Impurity 72 (C21H14F4N4O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Apalutamide Impurity 72 (CAS 1950587-19-5, C21H14F4N4O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Apalutamide Impurity 72 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H14F4N4O3S |
| Molecular Weight | 478.42 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Apalutamide Standards
- Apalutamide Impurity 99 (CAS CATO-C4X-274999)
- Apalutamide (CAS 956104-40-8)
- Apalutamide Impurity 77 (CAS CATO-C4X-274977)
- Apalutamide D3 (CAS 1638885-61-6)
- Apalutamide Impurity 56 (CAS CATO-C4X-274956)
- Apalutamide-13C-D3 (CAS 956104-40-8 (Unlabeled))
- Apalutamide Impurity 5 (CAS CATO-C4X-27495)
- Apalutamide Impurity 10 (CAS CATO-C4X-274910)
Recommended Standards
- 5-(((1R,1AS,6bR)-1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one (CAS 1446090-79-4)
- N-(2-Bromophenyl)-2-((3-ethyl-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 577960-68-0)
- Benzofuran Impurity 3 (CAS 1446090-77-2)
- Others Impurity 85 (CAS 731016-26-5)
- Ibuprofen EP Impurity N (CAS CATO-C4X-1082154)
- Imrecoxib Impurity 15-d7 (CAS 896729-07-0 (unlabelled))
- Baxdrostat Impurity 13 (CAS 3040129-67-4)
- 3-(4-Bromothiophen-2-yl)acrylaldehyde (CAS 1046162-02-0)
- (2R)-2-[(2-iodo-3-methylphenyl)formamido]propanoic acid (CAS 1604308-75-9)
- Tert-butyl 2-((4-bromophenyl)thio)-2-methylpropanoate (CAS 247923-30-4)
- Osimertinib Impurity 54 (CAS 27065-95-8)
- 1-Ethyl-2-(5-(1-ethyl-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-5-sulfonate (CAS 888014-73-1)
- 1,1,1-Trifluoro-3-(pyrazin-2-yl)propan-2-one (CAS 116655-36-8)
- Peptide Impurity 28 (CAS 1350456-64-2)
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