Allopurinol EP Impurity D CAS 19750-02-8
| CAS No. | 19750-02-8 |
| Molecular Formula | C6H9N3O2 |
| Molecular Weight | 155.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Allopurinol EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Allopurinol EP Impurity D (CAS 19750-02-8), a pharmacopoeial impurity reference standard (molecular formula C6H9N3O2, MW 155.15 g/mol) used for the identification and quantification of trace impurities in APIs.
Allopurinol EP Impurity D (C6H9N3O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C6H9N3O2 |
| Molecular Weight | 155.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Nitrogen Atoms | 3 |
Related Allopurinol Standards
- Allopurinol EP Impurity D (USP RC D) (CAS 1260243-04-6)
- Allopurinol EP Impurity D (CAS 6994-25-8)
- Allopurinol impurity 18 (CAS CATO-C4X-145818)
- Allopurinol EP Impurity B (CAS 22407-20-1)
- Allopurinol impurity 12 (CAS CATO-C4X-145812)
- Allopurinol impurity 27 (CAS CATO-C4X-145827)
- Allopurinol Impurity 31 (CAS CATO-C4X-145831)
- Allopurinol impurity 26 (CAS CATO-C4X-145826)
Recommended Standards
- 2,5-DImethoxypyridin-4-ol (CAS 1949816-18-5)
- 1-(Ethoxymethyl)-1H-1,2,3-triazole-5-carbaldehyde (CAS 197706-21-1)
- 4-Isopropyl-5-nitro-1H-imidazole (CAS 1936503-63-7)
- (1R,2S,3R,4S)-3-amino-7-oxabicyclo[2.2.1]Hept-5-ene-2-carboxylic acid (CAS 783340-43-2)
- Dapagliflozin Impurity 145 (CAS 1971128-00-3)
- Gadobutrol Impurity N50 (CAS 585531-74-4)
- Cefdinir Impurity 95 (CAS CATO-C4X-121095)
- 3-Azidopropanenitrile (CAS 23648-56-8)
- 4-[3-(Aminomethyl)-2-pyridinyl]-2-piperazinone (CAS 953894-31-0)
- methyl 2-amino-4-(propan-2-yl)-1,3-thiazole-5-carboxylate (CAS 649737-05-3)
- Methyl 1-(4-ethoxy-4-oxobutyl)-1h-pyrazole-5-carboxylate (CAS 1171386-33-6)
- ((2R,3S,4R,5R)-5-(6-(2-Acetylbenzamido)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate (CAS 398133-26-1)
- 1,3,5-Tribromo-2,4,6-trimethoxybenzene (CAS 105404-90-8)
- Peptide 6A (H-6905.0005) (CAS 73549-32-3)
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