Gadobutrol Impurity N50 CAS 585531-74-4
| CAS No. | 585531-74-4 |
| Molecular Formula | C32H60N4O8 |
| Molecular Weight | 628.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Gadobutrol Impurity N50 (C32H60N4O8) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 628.84 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Gadobutrol Impurity N50 (CAS 585531-74-4, C32H60N4O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C32H60N4O8 |
| Molecular Weight | 628.84 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Nitrogen Atoms | 4 |
Related Gadobutrol Standards
- Gadobutrol Impurity 187 (CAS CATO-C4X-2120187)
- Gadobutrol Impurity 9 (CAS 16695-22-0)
- Gadobutrol Impurity 8 (CAS 56187-04-3)
- Gadobutrol Impurity 5 （And Enantiomer） (CAS CATO-C4X-21205)
- Gadobutrol impurity 160 (CAS CATO-C4X-2120160)
- Gadobutrol impurity 168 (CAS CATO-C4X-2120168)
- Gadobutrol impurity 169 (CAS CATO-C4X-2120169)
- Gadobutrol impurity 170 (CAS CATO-C4X-2120170)
Recommended Standards
- Retigabine 3,3'-Dimer (CAS 1588430-16-3)
- 224186-03-2 Integracin A (CAS 224186-03-2)
- Bis(2,5-dioxopyrrolidin-1-yl) 11,11'-disulfanediyldiundecanoate (CAS 147072-47-7)
- Dexamethasone impurity 24 (CAS CATO-C4X-1165124)
- Ranitidine EP Impurity B (CAS 66356-53-4)
- Testosterone Impurity 28 (CAS CATO-C4X-132628)
- Cimetidine EP Impurity J 2HBr (CAS 38603-73-5)
- Benzyl 3-((2-amino-N-methylacetamido)methyl)pyrrolidine-1-carboxylate (CAS 1353954-95-6)
- D (CAS 139657-63-9)
- 3-(Di-i-propylphosphino)propylamine (CAS 1196147-69-9)
- 1,1-Bis(4-hydroxyphenyl)cyclohexane (CAS 843-55-0)
- (2R,3R,4S,5R,6S)-2-((benzoyloxy)methyl)-6-chlorotetrahydro-2H-pyran-3,4,5-triyl tribenzoate (CAS 27530-87-6)
- Lemborexant impurity 5 (CAS 2541020-22-6)
- Mast Cell Degranulating Peptide HR-1 (CAS 80533-94-4)
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