N-Nitroso Cetirizine EP Impurity A CAS 2005-04-1
| CAS No. | 2005-04-1 |
| Molecular Formula | C17H18ClN3O |
| Molecular Weight | 315.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N-Nitroso Cetirizine EP Impurity A is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
N-Nitroso Cetirizine EP Impurity A (CAS 2005-04-1) is a certified pharmaceutical impurity reference standard with the molecular formula C17H18ClN3O and a molecular weight of 315.80 g/mol.
Structurally, N-Nitroso Cetirizine EP Impurity A (C17H18ClN3O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 315.80 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), N-Nitroso Cetirizine EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H18ClN3O |
| Molecular Weight | 315.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related N Standards
- N-nitroso-hydroxyzine Impurity A (CAS CATO-C4X-16603)
- N-Nitroso Lomustine Impurity 2 (CAS 500545-48-2)
- N-Nitroso Abacavir EP Impurity A (CAS CATO-C4X-152715)
- N-Nitroso Naloxone EP impurity A (CAS CATO-C4X-149315)
- N-Nitroso Zolmitriptan (CAS CATO-C4X-135130)
- N-Nitroso Nerandomilast impurity 1 (CAS CATO-C4X-34731)
- N-Nitroso Chlorphenamine (CAS CATO-C4X-118844)
- N-Nitroso Articaine (CAS CATO-C4X-191215)
Recommended Standards
- N-(4-chlorophenyl)-4-phenylpiperazine-1-carboxamide (CAS 549544-51-6)
- Metoclopramide Impurity 42 (CAS 163082-23-3)
- N'-((2-Chloroquinolin-3-yl)methylene)cyclohexanecarbohydrazide (CAS 477733-17-8)
- Metoclopramide EP Impurity G (CAS 171367-22-9)
- Famotidine impurity 76 (CAS CATO-C4X-139276)
- Dapagliflozin Impurity 202 (CAS CATO-C4X-1138202)
- CAS 98790-48-8 (CAS 98790-48-8)
- (3-Methylbutanoyl)-l-valine (CAS 39741-06-5)
- 2-Isopropyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-isoindole (CAS 1149352-16-8)
- 6-Cyclopropyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine (CAS 1355173-79-3)
- N-(3-Aminopropyl)-4-fluorobenzamide (CAS 220586-07-2)
- 4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzeneundecanoic Acid (CAS 113274-80-9)
- 2-((Tert-butoxycarbonyl)amino)thieno[3,2-b]pyridine-3-carboxylic acid (CAS 1257420-62-4)
- Tirzepatide Impurity 9 (CAS CATO-C4X-32409)
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