N-Nitroso Nerandomilast impurity 1 CAS CATO-C4X-34731
| CAS No. | CATO-C4X-34731 |
| Molecular Formula | C11H13ClN4O3S |
| Molecular Weight | 316.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, N-Nitroso Nerandomilast impurity 1 (CAS CATO-C4X-34731, C11H13ClN4O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of N-Nitroso Nerandomilast impurity 1 (C11H13ClN4O3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H13ClN4O3S |
| Molecular Weight | 316.76 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related N Standards
- N-Nitroso Zolmitriptan (CAS CATO-C4X-135130)
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- N-Nitroso Chlorphenamine (CAS CATO-C4X-118844)
Recommended Standards
- Bupropion Impurity 59 (CAS CATO-C4X-120359)
- 6-(4-Chlorophenyl)-3-(furan-2-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine (CAS 183536-51-8)
- Bupropion Impurity 58 (CAS CATO-C4X-120358)
- 5-Amino-2-((2-chlorobenzyl)thio)-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile (CAS 878414-55-2)
- Ibuprofen impurity 144 (CAS CATO-C4X-1082144)
- Tirofiban Impurity 100 (CAS CATO-C4X-1254100)
- Febuxostat Impurity 96 (CAS CATO-C4X-116296)
- 4-Benzyloxyiodobenzene 1-benzyloxy-4-iodobenzene 4-iodobenzyloxybenzene 19578-68-8 (CAS 19578-68-8)
- 1-(6-(Azepan-1-yl)pyrimidin-4-yl)-1H-pyrazole-3-carboxylic acid (CAS 1713463-31-0)
- Fmoc-Homoarg(Pmc)-OH (CAS 214852-52-5)
- 6-Chloro-4-(chloromethyl)-7-methyl-2H-1-benzopyran-2-one (CAS 41295-60-7)
- 6-Bromo-1-methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (CAS 1174645-18-1)
- (1R,5S,7R)-rel-2-Oxabicyclo[3.2.0]heptan-7-amine hydrochloride (CAS 2740853-56-7)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
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