Canagliflozin Impurity 31 CAS 2005454-69-1
| CAS No. | 2005454-69-1 |
| Molecular Formula | C18H15FS |
| Molecular Weight | 282.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Canagliflozin Impurity 31.
As a process- or degradation-related impurity, Canagliflozin Impurity 31 (CAS 2005454-69-1, C18H15FS) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Canagliflozin Impurity 31 (C18H15FS) is characterized by sulfur-containing functionality, fluorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H15FS |
| Molecular Weight | 282.38 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Canagliflozin Standards
- Canagliflozin Impurity 17 (CAS 2069934-29-6)
- Canagliflozin Impurity 70 (CAS CATO-C4X-112370)
- Canagliflozin Impurity 72 (CAS CATO-C4X-112372)
- Canagliflozin Impurity 73 (CAS CATO-C4X-112373)
- Canagliflozin Impurity 74 (CAS CATO-C4X-112374)
- Canagliflozin Impurity 79 (CAS 2265214-90-0)
- Canagliflozin Impurity 4 (CAS CATO-C4X-11234)
- Canagliflozin Impurity 71 (CAS 1662702-88-6)
Recommended Standards
- Clopidogrel Impurity 59 (CAS 40412-09-7)
- Netupitant Impurity 11 (CAS CATO-C4X-122311)
- Clopidogrel Impurity 15 (CAS 40412-06-4)
- Netupitant Impurity 6 (CAS CATO-C4X-12236)
- Rotigotine impurity 22 (CAS CATO-C4X-192722)
- Blonanserin Impurity 12 (CAS 142838-82-2)
- Imidapril Impurity 4 (CAS CATO-C4X-24394)
- 5-(4-Chlorobenzoyl)-3-methylthieno[2,3-c][1,2]thiazol-4-amine (CAS 339017-37-7)
- 1-(2-Chloro-5-methoxyquinolin-3-yl)ethanone (CAS 1956367-18-2)
- Sebuthylazine-d5 (ethyl-d5) (CAS 1219805-56-7)
- N-(3-Aminophenyl)-2-(1-pyrrolidinyl)acetamide (CAS 891855-91-7)
- [4-(6-Methylquinolin-2-yl)phenyl]amine (CAS 1224953-47-2)
- Rhynchophylline (CAS 76-66-4)
- Semaglutide impurity 289 (CAS CATO-C4X-2226289)
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