Clopidogrel Impurity 59 CAS 40412-09-7
| CAS No. | 40412-09-7 |
| Molecular Formula | C13H14O3S2 |
| Molecular Weight | 282.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clopidogrel Impurity 59.
Clopidogrel Impurity 59 (CAS 40412-09-7) is a certified pharmaceutical impurity reference standard with the molecular formula C13H14O3S2 and a molecular weight of 282.38 g/mol.
Clopidogrel Impurity 59 (C13H14O3S2) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H14O3S2 |
| Molecular Weight | 282.38 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Sulfur Atoms | 2 |
Related Clopidogrel Standards
- Clopidogrel Impurity 15 (CAS 40412-06-4)
- Clopidogrel Impurity 120 (CAS CATO-C4X-1029120)
- Clopidogrel Impurity 78 (CAS CATO-C4X-102978)
- Clopidogrel Impurity 82 (CAS 1015247-87-6)
- Clopidogrel Impurity N1 (CAS 85567-51-7)
- Clopidogrel Impurity 24 (CAS CATO-C4X-102924)
- Clopidogrel Impurity 18 (CAS 444728-13-6)
- Clopidogrel EP Impurity E (R-Isomer) (CAS 444728-15-8)
Recommended Standards
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- Silodosin Impurity 29 (CAS 1251924-67-0)
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- Cyclopenta[b]pyrrole (CAS 250-36-2)
- 1-(6-Methylpyrimidin-4-yl)ethan-1-amine (CAS 1368919-13-4)
- Semaglutide impurity 261 (CAS CATO-C4X-2226261)
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