Ritonavir Impurity 1 CAS 201409-23-6
| CAS No. | 201409-23-6 |
| Molecular Formula | C14H22N3O3S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Ritonavir Impurity 1 (CAS 201409-23-6, C14H22N3O3SLi) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, Ritonavir Impurity 1 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 319.35 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Ritonavir Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H22N3O3S Li |
| Molecular Weight | 319.35 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2014 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Ritonavir Standards
- Ritonavir EP Impurity C (CAS 1010808-43-1)
- Ritonavir EP Impurity K (CAS 1010809-39-8)
- Ritonavir EP Impurity H (CAS 1010809-43-4)
- Ritonavir Impurity 45 (CAS 1010809-50-3)
- Ritonavir Impurity 46 (CAS 1010809-54-7)
- Ritonavir EP Impurity F (CAS 1010809-61-6)
- Ritonavir Dehydro (CAS 1156504-13-0)
- Ritonavir-13C3 (CAS 1217673-23-8)
Recommended Standards
- Trazodone impurity 61 (CAS 80714-38-1)
- Voriconazole Impurity 22 (CAS CATO-C4X-136622)
- Oxybutynin EP Impurity F (CAS 10399-13-0)
- 4-phenyl-1-(thien-2-ylsulfonyl)piperidine-4-carboxylic acid (CAS 793727-32-9)
- 1-Cyclobutylpiperidin-4-one (CAS 359880-05-0)
- Methyl Hydroxybenzoic Acid (CAS 586-30-1)
- n-Isopropyl-2-methyl-3-nitroaniline (CAS 1153195-65-3)
- N-(2-(piperazin-1-yl)phenyl)acetamide dihydrochloride (CAS 1417635-85-8)
- 4-Bromo-3-hydroxy-2-(trifluoromethyl)pyridine (CAS 1227591-89-0)
- Semaglutide impurity 66 (CAS CATO-C4X-222666)
Why CATO?
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