Glycopyrrolate Impurity 16 CAS 201667-20-1
| CAS No. | 201667-20-1 |
| Molecular Formula | C19H28NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 398.34 g/mol gives Glycopyrrolate Impurity 16 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Glycopyrrolate Impurity 16 (CAS 201667-20-1, C19H28NO3Br) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Glycopyrrolate Impurity 16 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 398.34 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H28NO3 Br |
| Molecular Weight | 398.34 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2014 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Glycopyrrolate Standards
- Glycopyrrolate Impurity 8 (CAS 104641-59-0)
- Glycopyrrolate Impurity 9 (CAS 104641-60-3)
- Glycopyrrolate Impurity 6 (CAS 1202407-99-5)
- Glycopyrrolate Impurity 6 (CAS 126497-27-6)
- Glycopyrrolate Impurity N13 (CAS 129784-11-8)
- Glycopyrrolate Impurity 12 (CAS 131237-81-5)
- Glycopyrrolate Impurity 5 (CAS 1404453-63-9)
- Glycopyrrolate Impurity 5 (CAS 207856-85-7)
Recommended Standards
- Rebamipide Impurity 46 (CAS CATO-C4X-152346)
- Entacapone EP Impurity D (CAS 857629-79-9)
- Canagliflozin Impurity 60 (CAS CATO-C4X-112360)
- 3-(3,4-DIMETHYL-1H-PYRROL-1-YL)-5-(TRIFLUOROMETHYL)-1H-INDAZOLE (CAS 2089650-22-4)
- 2-(4-(Dimethylamino)piperidin-1-yl)nicotinaldehyde (CAS 1707391-28-3)
- 1-Bromo-2-(difluoromethyl)-3,4-difluorobenzene (CAS 1804909-75-8)
- methyl 5-(trifluoromethyl)pyrimidine-2-carboxylate (CAS 1260664-64-9)
- 2-Fluoro-4-(furan-3-yl)benzaldehyde (CAS 1342057-65-1)
- 1-(2-(2,4-Dichlorophenyl)-4-methylthiazol-5-yl)ethan-1-one (CAS 1211847-16-3)
- (β-Asp5)-Delta-Sleep Inducing Peptide (CAS 82602-88-8)
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