Entacapone EP Impurity D CAS 857629-79-9
| CAS No. | 857629-79-9 |
| Molecular Formula | C16H19N3O5 |
| Molecular Weight | 333.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Entacapone EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Entacapone EP Impurity D (CAS 857629-79-9, C16H19N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Entacapone EP Impurity D is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 333.34 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H19N3O5 |
| Molecular Weight | 333.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 3 |
Related Entacapone Standards
- Entacapone impurity 20 (CAS CATO-C4X-162920)
- Entacapone Impurity 55 (CAS CATO-C4X-162955)
- Entacapone JP Impurity C (CAS CATO-C4X-162937)
- Entacapone Impurity 10 (CAS CATO-C4X-162910)
- Entacapone Impurity 11 (CAS CATO-C4X-162911)
- Entacapone impurity 50 (CAS CATO-C4X-162950)
- Entacapone Impurity 62 (CAS CATO-C4X-162962)
- Entacapone Impurity 21 (CAS 158693-04-0)
Recommended Standards
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- Rasagiline Impurity 47 (CAS 61341-86-4)
- Methyl 2-(pyridazin-3-yl)acetate (CAS 37444-32-9)
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- N-((1H-Pyrrol-2-yl)methylene)-2,4,6-trimethylaniline (CAS 383889-16-5)
- 4-Bromo-2,6-dichloro-3-methylaniline (CAS 62406-68-2)
- semaglutide (CAS 782487-28-9)
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