Tofacitinib Impurity 27 CAS 2028267-73-2
| CAS No. | 2028267-73-2 |
| Molecular Formula | C16H20N6O2 |
| Molecular Weight | 328.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tofacitinib Impurity 27 (CAS 2028267-73-2, C16H20N6O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Tofacitinib Impurity 27 (C16H20N6O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H20N6O2 |
| Molecular Weight | 328.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 6 |
Related Tofacitinib Standards
- Tofacitinib Impurity 119 (CAS 2407039-29-4)
- Tofacitinib Impurity 139 (CAS CATO-C4X-1079139)
- Tofacitinib Impurity 159 (CAS 1640971-51-2)
- Tofacitinib Impurity 171 (CAS CATO-C4X-1079171)
- Tofacitinib Impurity 231 (CAS 2101951-20-4)
- Tofacitinib Impurity 98 (CAS CATO-C4X-107998)
- Tofacitinib Impurity 232 (CAS CATO-C4X-1079232)
- Tofacitinib Impurity 120 (CAS CATO-C4X-1079120)
Recommended Standards
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- Olodaterol Impurity 12 (CAS CATO-C4X-194312)
- Ceritinib Impurity 83 (CAS CATO-C4X-104883)
- Paricalcitol Impurity 6 (CAS CATO-C4X-13876)
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- 2-chloro-8-methoxyquinazolin-4-amine (CAS 61948-65-0)
- Allo-D-Ile17-Tirzepatide (CAS CATO-CPTD788962)
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