Tofacitinib Impurity 119 CAS 2407039-29-4
| CAS No. | 2407039-29-4 |
| Molecular Formula | C16H20N6O2 |
| Molecular Weight | 328.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Tofacitinib Impurity 119 (CAS 2407039-29-4), a pharmacopoeial impurity reference standard (molecular formula C16H20N6O2, MW 328.37 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Tofacitinib Impurity 119 (C16H20N6O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 328.37 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tofacitinib Impurity 119 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H20N6O2 |
| Molecular Weight | 328.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Nitrogen Atoms | 6 |
Related Tofacitinib Standards
- Tofacitinib Impurity 139 (CAS CATO-C4X-1079139)
- Tofacitinib Impurity 159 (CAS 1640971-51-2)
- Tofacitinib Impurity 171 (CAS CATO-C4X-1079171)
- Tofacitinib Impurity 231 (CAS 2101951-20-4)
- Tofacitinib Impurity 27 (CAS 2028267-73-2)
- Tofacitinib Impurity 98 (CAS CATO-C4X-107998)
- Tofacitinib Impurity 232 (CAS CATO-C4X-1079232)
- Tofacitinib Impurity 120 (CAS CATO-C4X-1079120)
Recommended Standards
- Tert-butyl 2-amino-1-(2-hydroxyethyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylate (CAS 840461-15-6)
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- N1-Cyclohexyl-N2-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)oxalamide (CAS 946350-21-6)
- N,N-diethyl-4-((2-methoxy-4-nitrophenyl)diazenyl)aniline (CAS 6373-95-1)
- Fluconazole EP Impurity G (R-Isomer) (CAS CATO-C4X-101965)
- Ruilugoli lmpurity 127 (CAS CATO-C4X-2429127)
- Empagliflozin Impurity 301 (CAS CATO-C4X-1065301)
- Isopropyl 2-Morpholinopyridine-4-carboxylate (CAS 1047724-23-1)
- 6,7-Dimethylquinoline (CAS 20668-33-1)
- tert-Butyl N-[3-(1H-1,2,3,4-tetrazol-5-yl)cyclobutyl]carbamate (CAS 1638764-51-8)
- Octylammonium p-toluenesulfonate (CAS 61165-94-4)
- 5-Bromo-N-(2-(cyclopentylamino)-2-oxoethyl)furan-2-carboxamide (CAS 932869-10-8)
- 6-Hydroxy-3-phenyl-2-(trifluoromethyl)pyridine (CAS 1214380-66-1)
- D-Thr5-Tirzepatide (CAS CATO-CPTD788926)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com