Carboxyamidotriazole Impurity 1 CAS 203202-66-8
| CAS No. | 203202-66-8 |
| Molecular Formula | C14H8Cl4O |
| Molecular Weight | 334.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 334.02 g/mol gives Carboxyamidotriazole Impurity 1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Carboxyamidotriazole Impurity 1 (CAS 203202-66-8) is a certified pharmaceutical impurity reference standard with the molecular formula C14H8Cl4O and a molecular weight of 334.02 g/mol.
Carboxyamidotriazole Impurity 1 (C14H8Cl4O) contains a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H8Cl4O |
| Molecular Weight | 334.02 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | Cl-containing |
Related Carboxyamidotriazole Standards
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