Thiamine nitrate EP Impurity E CAS 299-35-4
| CAS No. | 299-35-4 |
| Molecular Formula | C12H16N4OS2 |
| Molecular Weight | 296.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Thiamine nitrate EP Impurity E is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Thiamine nitrate EP Impurity E (CAS 299-35-4, C12H16N4OS2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Thiamine nitrate EP Impurity E (C12H16N4OS2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Thiamine nitrate EP Impurity E under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H16N4OS2 |
| Molecular Weight | 296.41 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 2 |
Related Thiamine Standards
- Thiamine Impurity 3 (CAS 20166-17-0)
- Thiamine /Vitamin B1 Impurity 53 (CAS CATO-C4X-187353)
- Thiamine Nitrate EP Impurity D (CAS 490-82-4)
- Thiamine EP Impurity F (CAS 10593-44-9)
- Thiamine Impurity 32 (CAS 52164-53-1)
- Thiamine /Vitamin B1 Impurity 56 (CAS 1153-39-5)
- Thiamine Impurity 42 (CAS 38655-47-9)
- Thiamine (CAS 70-16-6)
Recommended Standards
- Tranexamic Acid EP Impurity E (CAS 82755-59-7)
- Piperazine Impurity 8 (CAS 769083-63-8)
- Netupitant Impurity 2 (CAS CATO-C4X-12232)
- Quinidine Impurity 3 (CAS 485-65-4)
- Lodoxamide lmpurity 9 (CAS 61313-43-7)
- 4-Chloro-3-sulfobenzoic acid (Bumetanide Impurity) (CAS 755698-62-5)
- Pivmecillinam Impurity 5 (CAS 64527-05-5)
- 3-((Hydroxyimino)methyl)benzonitrile (CAS 64847-76-3)
- 4-Amino-7-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (CAS 115044-83-2)
- tert-butyl 1,2,3,4-tetrahydroisoquinoline-4-carboxylate (CAS 1479898-20-8)
- (3,3-Difluorotetrahydro-2H-pyran-4-yl)methanamine (CAS 1780537-28-1)
- Etomidate Impurity 23 (CAS 112421-33-7)
- 5(S),12(R)-DiHETE(6-trans-LTB4) (CAS 71652-82-9)
- Liraglutide Impurity 30 (CAS CATO-C4X-199230)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com