Nintedanib Impurity 5 CAS 2036139-30-5
| CAS No. | 2036139-30-5 |
| Molecular Formula | C17H13NO4 |
| Molecular Weight | 295.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Nintedanib Impurity 5 (CAS 2036139-30-5) is a certified pharmaceutical impurity reference standard with the molecular formula C17H13NO4 and a molecular weight of 295.29 g/mol.
The molecular framework of Nintedanib Impurity 5 (C17H13NO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C17H13NO4 |
| Molecular Weight | 295.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 12 (CAS 2218446-42-3)
- Nintedanib Impurity 3 (CAS 2093243-16-2)
- Nintedanib Impurity 163 (CAS CATO-C4X-1814163)
- Nintedanib Impurity 166 (CAS 126434-07-9)
- Nintedanib Impurity 126 (CAS CATO-C4X-1814126)
- Nintedanib Impurity 130 (CAS CATO-C4X-1814130)
- Nintedanib Impurity 131 (CAS CATO-C4X-1814131)
- Nintedanib Impurity 159 (CAS CATO-C4X-1814159)
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