Nintedanib Impurity 3 CAS 2093243-16-2
| CAS No. | 2093243-16-2 |
| Molecular Formula | C17H13NO4 |
| Molecular Weight | 295.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Nintedanib Impurity 3 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Nintedanib Impurity 3 (CAS 2093243-16-2, C17H13NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Nintedanib Impurity 3 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 295.29 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H13NO4 |
| Molecular Weight | 295.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 12 (CAS 2218446-42-3)
- Nintedanib Impurity 5 (CAS 2036139-30-5)
- Nintedanib Impurity 163 (CAS CATO-C4X-1814163)
- Nintedanib Impurity 166 (CAS 126434-07-9)
- Nintedanib Impurity 126 (CAS CATO-C4X-1814126)
- Nintedanib Impurity 130 (CAS CATO-C4X-1814130)
- Nintedanib Impurity 131 (CAS CATO-C4X-1814131)
- Nintedanib Impurity 159 (CAS CATO-C4X-1814159)
Recommended Standards
- Omeprazole Impurity 44 (CAS CATO-C4X-125544)
- Penciclovir Impurity 2 (CAS 97845-80-2)
- Oxcarbazepine Impurity 22 (CAS 2642430-30-4)
- Roxadustat Impurity 64 (CAS 1509958-11-5)
- Indapamide Impurity 49 (CAS CATO-C4X-140049)
- Aclidinium bromide Impurity 2 (CAS 7333-07-5)
- Somatostatin Impurity 16 (CAS CATO-C4X-235016)
- 6-Bromo-4-(2-phenylmorpholin-4-yl)quinoline (CAS 1252528-26-9)
- 1-(2-Fluoro-3-hydroxy-6-nitrophenyl)propan-2-one (CAS 649736-31-2)
- (Z)-1-(2-(6-methoxy-2,2-dimethyl-3-thioxo-2,3-dihydroquinolin-4(1H)-ylidene)-5-phenyl-1,3-dithiol-4-yl)ethan-1-one (CAS 5968-78-5)
- 1-(4-(4-Methoxyphenyl)thiazol-2-yl)-4-(thiophen-3-yl)-1H-pyrazol-5-amine (CAS 955967-07-4)
- N-(4-Bromophenyl)-5-methyl-12-oxo-5H,5aH,6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide (CAS 1775409-06-7)
- 3-(1,2-oxazol-3-yl)propanoic acid (CAS 855747-49-8)
- Tirzepatide Impurity 57 (CAS CATO-C4X-324057)
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