Pemetrexed Impurity CAS 204257-65-8
| CAS No. | 204257-65-8 |
| Molecular Formula | C25H27N6O9 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Pemetrexed Impurity (CAS 204257-65-8) is a certified pharmaceutical impurity reference standard with the molecular formula C25H27N6O9Na and a molecular weight of 578.51 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Pemetrexed Impurity is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 578.51 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H27N6O9 Na |
| Molecular Weight | 578.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Nitrogen Atoms | 6 |
Related Pemetrexed Standards
- Pemetrexed Impurity 21 (CAS 1001-19-0)
- Pemetrexed Impurity 11 (CAS 100643-27-4)
- Pemetrexed Impurity 22 (CAS 1075-59-8)
- Pemetrexed Impurity 54 (CAS 1265908-58-4)
- Pemetrexed EP Impurity D Trisodium salt (CAS 1265908-59-5)
- Pemetrexed Impurity (CAS 1265908-60-8)
- Pemetrexed Impurity (CAS 1265908-61-9)
- Pemetrexed Impurity 53 (CAS 1320346-37-9)
Recommended Standards
- Adapalene Impurity 16 (CAS CATO-C4X-180916)
- Pemafibrate Impurity 98 (CAS CATO-C4X-290398)
- Dexmedetomidine Impurity 22 (CAS CATO-C4X-123022)
- Eperisone Impurity 32 (CAS CATO-C4X-227932)
- methyl 2-hydroxy-2-(3-methoxyphenyl)acetate (CAS 54845-40-8)
- 2-[2-(3-Methylbutoxy)phenyl]ethanamine (CAS 1179153-30-0)
- 4-Bromo-3-fluoro-5-methylaniline (CAS 1356113-07-9)
- 2-(6-Fluoro-1H-indazol-3-yl)acetic acid (CAS 1432128-09-0)
- (2S,4S)-pyrrolidine-2,4-dicarboxylic acid (CAS 64927-38-4)
- [Tyr15] Fibrinopeptide B, human (CAS 125455-56-3)
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