Brivaracetam Impurity 127 CAS 2052297-74-0
| CAS No. | 2052297-74-0 |
| Molecular Formula | C11H21ClN2O2 |
| Molecular Weight | 248.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Brivaracetam Impurity 127 (CAS 2052297-74-0) is a certified pharmaceutical impurity reference standard with the molecular formula C11H21ClN2O2 and a molecular weight of 248.75 g/mol.
Structurally, Brivaracetam Impurity 127 (C11H21ClN2O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 2.0, corresponding to approximately 2 ring(s) or double-bond equivalent(s). With a molecular weight of 248.75 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H21ClN2O2 |
| Molecular Weight | 248.75 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Brivaracetam Standards
- Brivaracetam Impurity 153 (CAS CATO-C4X-2007153)
- Brivaracetam Impurity 207 (CAS CATO-C4X-2007207)
- Brivaracetam Impurity 23 (CAS 112459-79-7)
- Brivaracetam Impurity 31 (CAS CATO-C4X-200731)
- Brivaracetam Impurity 167 (CAS CATO-C4X-2007167)
- Brivaracetam Impurity 170 (CAS CATO-C4X-2007170)
- Brivaracetam Impurity 191 (CAS CATO-C4X-2007191)
- Brivaracetam Impurity 181 (CAS CATO-C4X-2007181)
Recommended Standards
- Hydroxychloroquine impurity 83 (CAS CATO-C4X-183583)
- Hexachloropropene (CAS 1888-71-7)
- 2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexene-1-carboxaldehyde (CAS 1228837-05-5)
- 1-(benzylsulfanyl)-3-(chloromethyl)benzene (CAS 123926-49-8)
- Sevoflurane Impurity 6 (CAS 58109-33-4)
- Vericiguat Impurity 104 (CAS CATO-C4X-2896104)
- Torasemide Impurity 24 (CAS CATO-C4X-183624)
- FA-Gly-OH (CAS 124882-74-2)
- Pyrazolo[1,5-a]pyridine-3-carboximidamide (CAS 1552705-67-5)
- 3-(3-Amino-1H-pyrazol-4-yl)-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 1823184-32-2)
- 1-(Furan-2-yl)-N-((1-methyl-1H-pyrazol-3-yl)methyl)methanamine hydrochloride (CAS 1856035-80-7)
- (5,6,7,8-Tetrahydroisoquinolin-3-yl)methanol (CAS 37009-23-7)
- 3-(Benzo[d][1,3]dioxol-5-yl)-3-(1,4-dioxa-8-azaspiro[4.5]Decan-8-yl)propanoic acid (CAS 886361-92-8)
- Semaglutide impurity 74 (CAS CATO-C4X-222674)
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