Vonoprazan Impurity 147 CAS 748810-25-5
| CAS No. | 748810-25-5 |
| Molecular Formula | C11H7FN2O |
| Molecular Weight | 202.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Vonoprazan Impurity 147 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Vonoprazan Impurity 147 (CAS 748810-25-5), a pharmacopoeial impurity reference standard (molecular formula C11H7FN2O, MW 202.18 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Vonoprazan Impurity 147 (C11H7FN2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C11H7FN2O |
| Molecular Weight | 202.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Vonoprazan Standards
- Vonoprazan Fumarate impurity 1 (CAS 312307-38-3)
- Vonoprazan Impurity 148 (CAS 2304978-51-4)
- Vonoprazan Impurity 150 (CAS 312307-69-0)
- Vonoprazan Impurity 308 (CAS CATO-C4X-1020308)
- Vonoprazan Fumarate Impurity 61 (CAS 158692-52-5)
- Vonoprazan Impurity 103 (CAS CATO-C4X-1020103)
- Vonoprazan Impurity 262 (CAS CATO-C4X-1020262)
- Vonoprazan Impurity 217 (CAS 16420-39-6)
Recommended Standards
- N-Cyclopropyl-6-(trifluoromethyl)-2-pyridinamine (CAS 944580-74-9)
- N-Allyl-6-(trifluoromethyl)pyridin-2-amine (CAS 944580-75-0)
- n-Allyl-5-(trifluoromethyl)pyridin-2-amine (CAS 838870-83-0)
- Tedizolid Impurity 70 (CAS 2563929-79-1)
- Lasmiditan Impurity 28 (CAS CATO-C4X-247828)
- Ketoconazole Impurity 8 (Mixture of diastereomers) (CAS 68751-57-5)
- Relugolix Impurity 90 (CAS CATO-C4X-242990)
- N-(4-((5-(4-Aminophenoxy)pentyl)oxy)phenyl)-2-hydroxyacetamide (CAS 102009-04-1)
- (3-Acetoxy-5-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl acetate (CAS 6161-23-5)
- 1-(3-thienyl)propan-2-amine (CAS 149977-81-1)
- 2-Bromo-5-(oxolan-3-yl)-1,3,4-thiadiazole (CAS 1342036-39-8)
- [2-[(Methylthio)(2H-pyrrol-2-ylidene)methyl]-1H-pyrrole](difluoroborane) (CAS 892505-41-8)
- 1-Methyl-4-{5-methyl-4-[(oxolan-2-yl)methyl]-4H-1,2,4-triazol-3-yl}-1H-pyrazol-5-amine (CAS 956242-16-3)
- Met(O)14-Exenatide trifluoroacetate salt (CAS 1678417-38-3)
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