7-Bromo-4-chloro-8-fluoroquinazoline CAS 2089651-77-2
| CAS No. | 2089651-77-2 |
| Molecular Formula | C8H3BrClFN2 |
| Molecular Weight | 261.48 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
7-Bromo-4-chloro-8-fluoroquinazoline (CAS 2089651-77-2), molecular formula C8H3BrClFN2 and molecular weight 261.48 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 7-Bromo-4-chloro-8-fluoroquinazoline (C8H3BrClFN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H3BrClFN2 |
| Molecular Weight | 261.48 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
- 6-Bromo-2-chloro-5-fluoroquinazoline, 97% (CAS 1036756-07-6)
- 8-Bromo-4-chloro-5-fluoroquinazoline (CAS 1351499-20-1)
- 8-Bromo-4-chloro-6-fluoroquinazoline (CAS 1351499-77-8)
- 5-Bromo-4-chloro-8-fluoroquinazoline (CAS 1564693-03-3)
- 6-Bromo-4-chloro-8-fluoroquinazoline (CAS 1565583-08-5)
- 5-Bromo-2-chloro-7-fluoroquinoxaline (CAS 1881290-86-3)
- 7-Bromo-2-chloro-6-fluoroquinoxaline (CAS 1881295-54-0)
- 7-Bromo-4-chloro-6-fluoroquinazoline (CAS 1956334-41-0)
Recommended Standards
- 7-Bromo-4-chloro-6-fluorocinnoline (CAS 2759951-37-4)
- 8-Bromo-2-chloro-6-fluoroquinazoline (CAS 953039-63-9)
- 7-Bromo-4-chloro-5-fluoroquinazoline (CAS 2384687-59-4)
- 4-bromo-2,3-difluoro-benzoyl chloride (CAS 1349717-52-7)
- 3-Acetyl-8-methoxy-2H-cyclohepta[b]furan-2-one (CAS 1210-38-4)
- 2-Amino-N-(4-(N-cyclopropylacetamido)cyclohexyl)acetamide (CAS 1353946-23-2)
- 2-(3-Methylphenoxy)-1-{4-[6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl}ethan-1-one (CAS 1775453-37-6)
- 2-(3,5-Dimethyl-1H-pyrazol-1-yl)quinolin-8-ol (CAS 18239-59-3)
- 2-Chloro-6-cyanobenzene-1-sulfonyl chloride (CAS 1261499-21-1)
- Lansoprazole Impurity 48 (CAS CATO-C4X-161248)
- 5-(2-Fluorobenzylidene)-2-(piperazin-1-yl)thiazol-4(5H)-one (CAS 941943-69-7)
- Perampanel Impurity 8 (CAS CATO-C4X-24308)
- Ceftibuten Impurity 2 (CAS CATO-C4X-18902)
- endo-Ser39-Tirzepatide (CAS CATO-CPTD788935)
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