Riboflavin Impurity 14 CAS 21079-31-2
| CAS No. | 21079-31-2 |
| Molecular Formula | C14H12N4O4 |
| Molecular Weight | 300.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Riboflavin Impurity 14 (CAS 21079-31-2, C14H12N4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Riboflavin Impurity 14 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 300.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H12N4O4 |
| Molecular Weight | 300.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 4 |
Related Riboflavin Standards
- Riboflavin Impurity 13 (CAS 4250-90-2)
- Riboflavin EP Impurity C (CAS 2535-20-8)
- Riboflavin Impurity 37 (CAS 14684-48-1)
- Riboflavin Impurity 29 (CAS CATO-C4X-181929)
- Riboflavin EP Impurity A (CAS 1088-56-8)
- Riboflavin Impurity N18 (CAS 3051-94-3)
- Riboflavin Impurity 12 (CAS 64480-68-8)
- Riboflavin EP Impurity B (CAS 1086-80-2)
Recommended Standards
- TERT-BUTYL 2-HYDROXYETHYL(2-(2,2,2-TRIFLUOROACETAMIDO)ETHYL)CARBAMATE (CAS 364056-55-3)
- Sibutramine Impurity 6 (CAS 2758418-79-8)
- N,N'-Bis(2,3-methylenedioxyphenyl)urea (CAS 97174-59-9)
- Dexrazoxane Impurity 4 (CAS CATO-C4X-20204)
- Sildenafil Impurity N6 (CAS 1004455-71-3)
- Brexpiprazole impurity 72 (CAS CATO-C4X-113172)
- Perampanel Impurity 16 (CAS 381233-78-9)
- Cyclododecene (CAS 1501-82-2)
- 2,4-Di-tert-butyl-6-nitrophenyl methyl carbonate (CAS 873055-56-2)
- [5]Cycloparaphenylene (CAS 96100-94-6)
- (5-Bromo-1H-imidazol-2-yl)methanamine (CAS 944903-88-2)
- 8-(Prop-2-yn-1-yl)-1,4-dioxa-8-azaspiro[4.5]decane (CAS 263148-97-6)
- n-(2-Cyanoethyl)-2-((2-fluorophenyl)thio)-N-methylacetamide (CAS 1095167-82-0)
- Anti-Inflammatory Peptide 2 (CAS 118850-72-9)
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