Efavirenz Impurity 8 CAS 211563-40-5
| CAS No. | 211563-40-5 |
| Molecular Formula | C15H13ClF3NO3 |
| Molecular Weight | 347.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Efavirenz Impurity 8 (C15H13ClF3NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Efavirenz Impurity 8 (CAS 211563-40-5, C15H13ClF3NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Efavirenz Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H13ClF3NO3 |
| Molecular Weight | 347.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2017 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Efavirenz Standards
- Efavirenz Impurity 27 (CAS CATO-C4X-162727)
- Efavirenz RC 2 (CAS 173676-54-5)
- Efavirenz Impurity 26 (CAS 2177283-35-9)
- Efavirenz Impurity 7 (CAS 211563-41-6)
- Efavirenz Impurity (6-chloro-4-[2-(2-methylcyclopropyl)ethynyl]-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one) (CAS 1217623-65-8)
- Efavirenz-13C6 (CAS 1261394-62-0)
- rac Efavirenz-d5(major) (CAS 1132642-95-5)
- rac Efavirenz-d4 (CAS 1246812-58-7)
Recommended Standards
- N-(3-Chlorophenyl)Carbamic Acid 2-Fluoro-4-(Fluorosulfonyl)Phenyl Ester (CAS 23379-26-2)
- Esaxerenone Impurity 8 (CAS CATO-C4X-34488)
- Ethyl 1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-3,5-dimethyl-1H-pyrazole-4-carboxylate (CAS 956193-68-3)
- (E)-7-chloro-5-(2-fluorophenyl)-2-(nitromethylene)-2,3-dihydro-1H-benzo[e][1,4]diazepine 4-oxide (CAS 60656-76-0)
- Regadenoson Impurity 34 (CAS 13406-50-3)
- Clonazepam Impurity 23 (CAS CATO-C4X-140323)
- Adrenaline EP Impurity C (CAS 99-45-6)
- (4-Methoxy-3-nitrophenyl)methanol (CAS 41870-24-0)
- 1-(4-Chloro-2-methylphenyl)propan-1-one (CAS 1034980-59-0)
- 2-(3,4-Difluorophenyl)pyrrolidine hydrochloride (CAS 1197234-09-5)
- 2-Bromopyridin-3-yl trifluoromethanesulfonate (CAS 157373-97-2)
- Methyl 3-amino-3-cyclohexylpropanoate (CAS 757169-91-8)
- 2-(3-Nitrophenyl)benzoic acid (CAS 37174-74-6)
- His-Cyclic-Semaglutide (CAS CATO-C4X-2226182)
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