Efavirenz Impurity 27 CAS CATO-C4X-162727
| CAS No. | CATO-C4X-162727 |
| Molecular Formula | C16H15ClF3NO2 |
| Molecular Weight | 345.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Efavirenz Impurity 27 (CAS CATO-C4X-162727, C16H15ClF3NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Efavirenz Impurity 27 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 345.74 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Efavirenz Impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H15ClF3NO2 |
| Molecular Weight | 345.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ＞95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Efavirenz Standards
- Efavirenz Impurity 8 (CAS 211563-40-5)
- Efavirenz RC 2 (CAS 173676-54-5)
- Efavirenz Impurity 26 (CAS 2177283-35-9)
- Efavirenz Impurity 7 (CAS 211563-41-6)
- Efavirenz Impurity (6-chloro-4-[2-(2-methylcyclopropyl)ethynyl]-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one) (CAS 1217623-65-8)
- Efavirenz-13C6 (CAS 1261394-62-0)
- rac Efavirenz-d5(major) (CAS 1132642-95-5)
- rac Efavirenz-d4 (CAS 1246812-58-7)
Recommended Standards
- 2-Chloro-4-nitro-N-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)benzamide (CAS 922000-35-9)
- (4-Chloro-6,7-dimethoxyquinolin-3-yl)(4-fluorophenyl)methanone (CAS 1351780-15-8)
- 2-{[(E)-3-(4-Chloro-3-nitrophenyl)-2-propenoyl]amino}benzenecarboxamide (CAS 532957-26-9)
- Methyl 4-((3-chlorobenzyl)oxy)-6-fluoroquinoline-2-carboxylate (CAS 1357936-14-1)
- Roxithromycin EP Impurity I TFA salt (CAS 425365-66-8(free base))
- Nintedanib impurity 81 (CAS CATO-C4X-181481)
- Mirabegron Impurity 128 (CAS CATO-C4X-1032128)
- [1-(1-Benzofuran-2-yl)ethyl](propyl)amine (CAS 1016826-77-9)
- 3-(O-tolyl)prop-2-yn-1-ol (CAS 35851-37-7)
- N-Nitroso Carbamazepine EP Impurity E (N-Nitroso Clomipramine HCl EP Impurity E) (CAS 7458-08-4)
- Ethyl 2-Cyano-3-((4-Nitro-2-(Trifluoromethyl)Phenyl)Amino)Acrylate (CAS 954118-33-3)
- [6-[tert-butyl(dimethyl)silyl]oxy-2-naphthyl]boronic acid (CAS 179942-45-1)
- Benzyl (3R)-3-methanesulfonylpyrrolidine-1-carboxylate (CAS 2102409-37-8)
- Semaglutide Impurity 189 (CAS CATO-C4X-2226189)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com