Dapagliflozin Impurity 203 CAS 2133407-77-7
| CAS No. | 2133407-77-7 |
| Molecular Formula | C22H27ClO7 |
| Molecular Weight | 438.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dapagliflozin Impurity 203 is closely related to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Dapagliflozin Impurity 203 (CAS 2133407-77-7, C22H27ClO7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H27ClO7, Dapagliflozin Impurity 203 contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 438.90 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dapagliflozin Impurity 203 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H27ClO7 |
| Molecular Weight | 438.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 119 (CAS CATO-C4X-1138119)
- Dapagliflozin Impurity 139 (CAS CATO-C4X-1138139)
- Dapagliflozin Impurity 181 (CAS CATO-C4X-1138181)
- Dapagliflozin Impurity 187 (CAS CATO-C4X-1138187)
- Dapagliflozin Impurity 209 (CAS CATO-C4X-1138209)
- Dapagliflozin Impurity 210 (CAS CATO-C4X-1138210)
- Dapagliflozin Impurity 46 (CAS 461432-24-6)
- Dapagliflozin Impurity 65 (CAS CATO-C4X-113865)
Recommended Standards
- Canagliflozin Impurity 90 (CAS CATO-C4X-112390)
- Dapagliflozin Impurity 74 (CAS CATO-C4X-113874)
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- Dapagliflozin Impurity 86 (CAS 1528636-07-8)
- Amikacin Impurity 21 (CAS 40371-54-8)
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