Dapagliflozin Impurity 46 CAS 461432-24-6
| CAS No. | 461432-24-6 |
| Molecular Formula | C22H27ClO7 |
| Molecular Weight | 438.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dapagliflozin Impurity 46 is closely related to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Dapagliflozin Impurity 46 (CAS 461432-24-6), a pharmacopoeial impurity reference standard (molecular formula C22H27ClO7, MW 438.90 g/mol) used for the identification and quantification of trace impurities in APIs.
Dapagliflozin Impurity 46 (C22H27ClO7) contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Dapagliflozin Impurity 46 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H27ClO7 |
| Molecular Weight | 438.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 119 (CAS CATO-C4X-1138119)
- Dapagliflozin Impurity 139 (CAS CATO-C4X-1138139)
- Dapagliflozin Impurity 181 (CAS CATO-C4X-1138181)
- Dapagliflozin Impurity 187 (CAS CATO-C4X-1138187)
- Dapagliflozin Impurity 203 (CAS 2133407-77-7)
- Dapagliflozin Impurity 209 (CAS CATO-C4X-1138209)
- Dapagliflozin Impurity 210 (CAS CATO-C4X-1138210)
- Dapagliflozin Impurity 65 (CAS CATO-C4X-113865)
Recommended Standards
- Dapagliflozin Impurity 74 (CAS CATO-C4X-113874)
- Dapagliflozin Impurity 86 (CAS 1528636-07-8)
- Dapagliflozin Impurity 9 (CAS 714269-57-5)
- Pemafibrate Impurity 91 (CAS CATO-C4X-290391)
- Pramipexole Impurity 83 DiHCl (CAS 104632-25-9)
- Oxytocin Impurity 23 (CAS CATO-C4X-206623)
- Loratadine Impurity 41 (CAS CATO-C4X-142641)
- N-(4-Bromophenyl)-2-((5-(4-chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 477330-61-3)
- Melarsoprol, 97% (CAS 494-79-1)
- LCZ-696 Impurity 15 (CAS 149709-49-9)
- 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-(thiophen-2-yl)-1,3-thiazole (CAS 111836-91-0)
- 3-(3,4-Dimethoxyphenyl)-2-sulfanyl-3,4-dihydroquinazolin-4-one (CAS 422274-46-2)
- [4,4'-Bipyrimidine]-2,2',6,6'(1H,1'H,3H,3'H)-tetraone (CAS 59549-58-5)
- Semaglutide Impurity 185 (CAS CATO-C4X-2226185)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com