Bupropion Impurity 21 CAS 2133460-42-9
| CAS No. | 2133460-42-9 |
| Molecular Formula | C12H14ClNO3S |
| Molecular Weight | 287.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Bupropion Impurity 21 (CAS 2133460-42-9, C12H14ClNO3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Bupropion Impurity 21 (C12H14ClNO3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H14ClNO3S |
| Molecular Weight | 287.76 g/mol |
| Purity | >70% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Bupropion Standards
- Bupropion Impurity 4 (CAS 1246812-57-6)
- Bupropion Impurity 22 (CAS 2133460-43-0)
- Bupropion Impurity 25 (CAS CATO-C4X-120325)
- Bupropion Impurity 31 (CAS CATO-C4X-120331)
- Bupropion Impurity 16 (CAS 76650-08-3)
- Bupropion Impurity 9 (CAS 103175-61-7)
- Bupropion Impurity 20 (CAS 1261791-08-5)
- Bupropion Impurity 15 (CAS 92821-91-5)
Recommended Standards
- Methyl 2-(3-chloropropanamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate (CAS 551910-46-4)
- Methyl 2-(2-chloroacetamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate (CAS 300559-61-9)
- Trimethyllead Chloride (CAS 1520-78-1)
- Methyl (3-chloro-4-dimethylthiocarbamoyloxyphenyl)-acetate (CAS 91373-91-0)
- Furosemide Impurity 48 Sodium Salt (CAS 133989-65-8（free base）)
- Ilaprazole Impurity 50 (CAS 2285346-38-3 (free base))
- Ivermectin EP Impurity K (CAS 74567-01-4)
- 5-oxaspiro[2.5]octan-4-one (CAS 22566-31-0)
- N-(2-aminobenzyl)-1-benzylpiperidin-4-amine (CAS 79099-03-9)
- (6-Chloro-2-fluoropyridin-3-yl)methanamine (CAS 1379379-36-8)
- Ramelteon Impurity 25 HCI (CAS 1174496-11-7)
- 3-Hydrazinyl-6-phenylpyridazine 38956-80-8 5055AB C10H10N4 (CAS 38956-80-8)
- 3-Fluoro-4-methylpyridin-2-amine (CAS 1003710-35-7)
- Insulin Degludec Impurity 13 (CAS CATO-C4X-215713)
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