Bupropion Impurity 16 CAS 76650-08-3
| CAS No. | 76650-08-3 |
| Molecular Formula | C9H8Br2O |
| Molecular Weight | 291.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Bupropion Impurity 16 (CAS 76650-08-3) is a certified pharmaceutical impurity reference standard with the molecular formula C9H8Br2O and a molecular weight of 291.97 g/mol.
Owing to a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system, Bupropion Impurity 16 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 291.97 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8Br2O |
| Molecular Weight | 291.97 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Br-containing |
Related Bupropion Standards
- Bupropion Impurity N1 (CAS 30070-63-4)
- Bupropion Impurity 25 (CAS CATO-C4X-120325)
- Bupropion Impurity 31 (CAS CATO-C4X-120331)
- Bupropion Impurity 4 (CAS 1246812-57-6)
- Bupropion Impurity 21 (CAS 2133460-42-9)
- Bupropion Impurity 22 (CAS 2133460-43-0)
- Bupropion Impurity 43 (CAS CATO-C4X-120343)
- Bupropion Impurity 9 (CAS 103175-61-7)
Recommended Standards
- N-Allyl-3,5-dibromopyridin-2-amine (CAS 98545-74-5)
- 3,5,6,8-Tetrachloroacenaphthene (CAS 100125-35-7)
- 6-Methyl-2-bromomethyl benzoylbromide (CAS 755030-83-2)
- 3,4-Dibromo-2-methyltetrahydrothiophene 1,1-dioxide (CAS 100516-83-4)
- Fluoxetine EP Impurity A (CAS 42142-52-9)
- Pazufloxacin Impurity 1 (CAS CATO-C4X-23321)
- Palbociclib Impurity 182 (CAS CATO-C4X-1125182)
- 2-(4-(Benzyloxy)-2-nitrophenyl)acetic acid (CAS 6860-79-3)
- N-(3-chloro-4-methylphenyl)-2-((4,6-dimethylpyrimidin-2-yl)thio)acetamide (CAS 312266-80-1)
- 4-chloro-7-(trifluoromethyl)pyrido[3,2-d]pyrimidine (CAS 1256834-22-6)
- 7-Fluoro-3,4-dihydro-2H-1,4-benzoxazine-3-methanol (CAS 1021860-56-9)
- 6-fluoro-1-methyl-benzimidazole-4-carboxylic acid (CAS 2306264-85-5)
- 5-(3,4-Dihydro-2H-pyrrol-5-yl)-3-methyl-2-(piperidin-1-yl)pyridine (CAS 1352490-78-8)
- Des-Pro-Pro-Tirzepatide (CAS CATO-CPTD788696)
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