Bupropion Impurity 22 CAS 2133460-43-0
| CAS No. | 2133460-43-0 |
| Molecular Formula | C12H14ClNO3S |
| Molecular Weight | 287.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Bupropion Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Bupropion Impurity 22 (CAS 2133460-43-0) is a certified pharmaceutical impurity reference standard with the molecular formula C12H14ClNO3S and a molecular weight of 287.76 g/mol.
The molecular framework of Bupropion Impurity 22 (C12H14ClNO3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H14ClNO3S |
| Molecular Weight | 287.76 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Bupropion Standards
- Bupropion Impurity 4 (CAS 1246812-57-6)
- Bupropion Impurity 21 (CAS 2133460-42-9)
- Bupropion Impurity 25 (CAS CATO-C4X-120325)
- Bupropion Impurity 31 (CAS CATO-C4X-120331)
- Bupropion Impurity 16 (CAS 76650-08-3)
- Bupropion Impurity 9 (CAS 103175-61-7)
- Bupropion Impurity 20 (CAS 1261791-08-5)
- Bupropion Impurity 15 (CAS 92821-91-5)
Recommended Standards
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