Rosiglitazone Impurity 3 CAS 2142519-15-9

Description

Compared with other compounds in its class, the molecular weight of 209.29 g/mol gives Rosiglitazone Impurity 3 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Rosiglitazone Impurity 3 (CAS 2142519-15-9) is a certified pharmaceutical impurity reference standard with the molecular formula C11H19N3O and a molecular weight of 209.29 g/mol.

The molecular framework of Rosiglitazone Impurity 3 (C11H19N3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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