Rosiglitazone Impurity (5-[4-N-(2-Pyridylamino)ethoxy]benzylidene] thiazolidine-2,4-dione) CAS 643764-88-9
| CAS No. | 643764-88-9 |
| Molecular Formula | C17H15N3O3S |
| Molecular Weight | 341.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Rosiglitazone Impurity (5-[4-N-(2-Pyridylamino)ethoxy]benzylidene] thiazolidine-2,4-dione) (CAS 643764-88-9), a pharmacopoeial impurity reference standard (molecular formula C17H15N3O3S, MW 341.38 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Rosiglitazone Impurity (5-[4-N-(2-Pyridylamino)ethoxy]benzylidene] thiazolidine-2,4-dione) (C17H15N3O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 341.38 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H15N3O3S |
| Molecular Weight | 341.38 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Rosiglitazone Standards
- Rosiglitazone Impurity 6 (CAS CATO-C4X-21796)
- Rosiglitazone (CAS 122320-73-4)
- Rosiglitazone-d3 (CAS 1132641-22-5)
- Rosiglitazone Impurity 4 (CAS CATO-C4X-21794)
- Rosiglitazone Sodium (CAS 316371-83-2)
- Rosiglitazone Impurity 2 (CAS 1797979-55-5)
- Rosiglitazone Impurity 3 (CAS 2142519-15-9)
- Rosiglitazone N-(2-Succinic Acid) (CAS 956239-35-3)
Recommended Standards
- Prop-2-en-1-yl 6-[4-(4-fluorophenyl)piperazin-1-yl]pyridine-3-carboxylate (CAS 339011-31-3)
- Trans 1-Benzyl-4-(4-fluorophenyl)-6-oxopiperidine-3-carboxylic Acid Methyl Ester (CAS 612095-72-4)
- N1-(Benzo[d]thiazol-2-yl)-N2-(2-ethoxyphenyl)oxalamide (CAS 920229-78-3)
- Axitinib Impurity 48 (CAS 1959572-98-5)
- Clonazepam impurity 11 (CAS CATO-C4X-140311)
- Itraconazole Impurity 37 (CAS 154003-23-3)
- Apixaban Impurity 30 (CAS 1686149-78-9)
- 2,2-Difluoro-1-(4-phenoxyphenyl)ethanone (CAS 1352222-93-5)
- Pregabalin Impurity 60 (CAS 181289-33-8)
- 6-Piperidin-4-yl-2,3-dihydro-1H-indole (CAS 914223-14-6)
- (3-Amino-4-methylphenyl)(3,4-dimethoxyphenyl)methanone (CAS 1176617-34-7)
- N-Allyl-2-amino-3-phenylpropanamide hydrochloride (CAS 1236261-01-0)
- 2-(3-Bromophenyl)-4-(chloromethyl)thiazole hydrochloride (CAS 1052539-88-4)
- [Glu]17-Semaglutide (CAS CATO-CPTD788604)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com