Gefitinib Impurity 49 CAS 214472-41-0
| CAS No. | 214472-41-0 |
| Molecular Formula | C16H24N2O5 |
| Molecular Weight | 324.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Gefitinib Impurity 49 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 324.37 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Gefitinib Impurity 49 (CAS 214472-41-0) is a certified pharmaceutical impurity reference standard with the molecular formula C16H24N2O5 and a molecular weight of 324.37 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Gefitinib Impurity 49 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H24N2O5 |
| Molecular Weight | 324.37 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2018 |
| Nitrogen Atoms | 2 |
Related Gefitinib Standards
- Gefitinib Impurity 27 (CAS 861453-12-5)
- Gefitinib Impurity 89 (CAS CATO-C4X-111789)
- Gefitinib Impurity 48 (CAS 1006378-06-8)
- Gefitinib Impurity 54 (CAS 675126-26-8)
- Gefitinib impurity 68 (CAS CATO-C4X-111768)
- Gefitinib impurity 69 (CAS CATO-C4X-111769)
- Gefitinib Impurity 7 (CAS 184475-71-6)
- Gefitinib impurity 64 (CAS CATO-C4X-111764)
Recommended Standards
- Azelnidipine Impurity 11 (CAS CATO-C4X-104011)
- Trimethoprim EP Impurity I (CAS CATO-C4X-122519)
- 2H-1-Benzopyran-2-one,8-[1-(acetyloxy)-3- methyl-2-oxobutyl]-7-methoxy-,(+)- 95360-22-8 (CAS 95360-22-8)
- Trimethoprim EP Impurity I (E-Isomer) (CAS 118791-61-0)
- Bilastine Impurity 37 (CAS 552301-45-8)
- Eldecalcitol Impurity 47 (CAS 146434-16-4)
- Lercanidipine Impurity 78 (CAS CATO-C4X-136478)
- Bis-CH2-PEG2-acid (CAS 2250056-38-1)
- (±)17,18-DiHETE (CAS 116477-53-3)
- Ethyl 5-methyl-4-(propan-2-yl)-4h-1,2,4-triazole-3-carboxylate (CAS 1343195-97-0)
- 1-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)ethan-1-one (CAS 741709-59-1)
- 2-Amino-4-(4-methoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile (CAS 119825-06-8)
- Benzyl (E)-2-(naphthalen-2-yl)diazene-1-carboxylate (CAS 2138504-44-4)
- (9-D-Asp) Semaglutide X Sodium salt (CAS CATO-CPTD788617)
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