Levothyroxine phenolic glucuronide CAS 21462-56-6
| CAS No. | 21462-56-6 |
| Molecular Formula | C21H19I4NO10 |
| Molecular Weight | 952.99 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO supplies Levothyroxine phenolic glucuronide (CAS 21462-56-6), a certified reference material (molecular formula C21H19I4NO10, MW 952.99 g/mol) for analytical method development and quality control.
The molecular framework of Levothyroxine phenolic glucuronide (C21H19I4NO10) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H19I4NO10 |
| Molecular Weight | 952.99 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Levothyroxine Standards
- Levothyroxine acyl glucuronide (CAS 909880-81-5)
- Levothyroxine Impurity 57 (CAS CATO-C4X-167857)
- Levothyroxine Impurity 58 (CAS CATO-C4X-167858)
- Levothyroxine Impurity 29（Mixture of Diastereomers） (CAS CATO-C4X-167829)
- Levothyroxine Impurity 50 (CAS CATO-C4X-167850)
- Levothyroxine Impurity 51 (CAS CATO-C4X-167851)
- Levothyroxine (CAS CATO-C4X-167855)
- Levothyroxine Impurity 54 (CAS CATO-C4X-167854)
Recommended Standards
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