Prednisone Impurity 5 CAS 215095-77-5
| CAS No. | 215095-77-5 |
| Molecular Formula | C21H26O6 |
| Molecular Weight | 374.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Prednisone Impurity 5 (CAS 215095-77-5, C21H26O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Prednisone Impurity 5 (C21H26O6) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H26O6 |
| Molecular Weight | 374.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2018 |
Related Prednisone Standards
- Prednisone Impurity 14 (CAS 94088-91-2)
- Prednisone Impurity 12 (CAS CATO-C4X-169412)
- Prednisone Impurity 28 (20(S)-Hydroxy Methylprednisolone) (CAS 387-66-6)
- Prednisone Impurity 29 (20(R)-Hydroxy Methylprednisolone) (CAS 387-65-5)
- Prednisone-d8 (CAS CATO-C4X-191927)
- Prednisone-d8 (CAS CATO-CCAD300850)
- Prednisone Impurity N56 (CAS 103466-44-0)
- Prednisone-d7 (Major) (CAS CATO-C4X-191926)
Recommended Standards
- Ketoprofen Impurity 68 (CAS CATO-C4X-147168)
- Prednisolone Impurity 19 (CAS 61549-70-0)
- Conjugated Estrogens EP Impurity A (CAS 56050-04-5)
- Prednisolone impurity 59 (CAS CATO-C4X-173759)
- Oseltamivir Impurity 120 (CAS CATO-C4X-1720120)
- Carbidopa impurity 39 (CAS 2354546-08-8)
- Ubrogepant Impurity 4 (CAS CATO-C4X-34024)
- 4-Chloro-2,6-difluorophenylmethylsulfone (CAS 1208076-08-7)
- Solerole (CAS 27610-27-1)
- 1-(3-Bromo-5-fluorobenzyl)-1h-1,2,4-triazol-3-amine (CAS 1508220-36-7)
- 5,7-Dimethoxy-3-(4-methoxyphenyl)isobenzofuran-1(3H)-one (CAS 922169-96-8)
- 1-(2-Methyl-4-nitrophenyl)pyrrolidine (CAS 67828-58-4)
- N1-Acetyl Triethylenetetramine (CAS 141998-21-2)
- Semaglutide impurity 29 (CAS 110990-08-4)
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