1-(2-Chloro-6-fluorobenzyl)piperazine CAS 215655-20-2
| CAS No. | 215655-20-2 |
| Molecular Formula | C11H14ClFN2 |
| Molecular Weight | 228.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(2-Chloro-6-fluorobenzyl)piperazine (CAS 215655-20-2) is a high-purity analytical reference standard with the molecular formula C11H14ClFN2 and a molecular weight of 228.69 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution, 1-(2-Chloro-6-fluorobenzyl)piperazine is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 228.69 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H14ClFN2 |
| Molecular Weight | 228.69 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2018 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 5-Chloro-2-cyclohexylamino-3-fluoropyridine (CAS 1020253-24-0)
- 1-[(2-Chloro-4-fluorophenyl)methyl]piperazine (CAS 118630-33-4)
- (2-Chloro-6-fluorophenyl)(cyclopentyl)methanol (CAS 1225687-12-6)
- 1-[(3-Chloro-2-fluorophenyl)methyl]piperazine (CAS 1240565-18-7)
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- 1-(2-Chloro-4-fluorobenzyl)pyrrolidin-3-amine (CAS 1247243-31-7)
- 1-(5-Chloro-2-fluorobenzyl)piperazine (CAS 1251127-61-3)
- (3-Chloro-4-fluorophenyl)(cyclopentyl)methanol (CAS 1339640-22-0)
Recommended Standards
- (6,6-Dimethyl-1,4-dioxan-2-yl)methanesulfonyl chloride (CAS 2138584-95-7)
- 1-(3-Chloro-4-fluorophenyl)-3,3-dimethylbutan-1-one (CAS 898764-66-4)
- 2-Methoxy-2-(oxolan-3-yl)ethane-1-sulfonyl chloride (CAS 1890032-75-3)
- 1-(4-Chloro-3-fluorophenyl)-2,2-dimethylbutan-1-one (CAS 898765-70-3)
- Tert-butyl (3-ethynylazetidin-3-yl)carbamate (CAS 2092107-40-7)
- 2-(Benzo[d]thiazol-2-yl)propanoic acid (CAS 209742-72-3)
- 5'-Bromospiro[cyclohexane-1,3'-indole] (CAS 1375076-88-2)
- Iodo-PEG2-C2-Boc (CAS 1938057-43-2)
- Fasudil impurity 66 (CAS CATO-C4X-136566)
- (2,5-Diphenyloxazol-4-yl)methanol (CAS 2549-35-1)
- 2-(Bromomethyl)-3,5-difluoropyridine (CAS 1227516-28-0)
- 2,2-Bis(dodecylthio)-4,15-dioxo-5,8,11,14-tetraoxaoctadecane-1,18-dioic acid (CAS 88449-92-7)
- 2-[(E)-2-[(4-Methoxyphenyl)amino]ethenyl]-4-(trifluoromethyl)-1,3-thiazole-5-carbonitrile (CAS 339026-52-7)
- Semaglutide Impurity 7 (CAS CATO-C4X-22267)
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