Tofacitinib Impurity 96 CAS 2174011-55-1
| CAS No. | 2174011-55-1 |
| Molecular Formula | C16H20N6O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Tofacitinib Impurity 96 (CAS 2174011-55-1), a pharmacopoeial impurity reference standard (molecular formula C16H20N6OC6H8O7, MW 504.50 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Tofacitinib Impurity 96 (C16H20N6OC6H8O7) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 504.50 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H20N6O C6H8O7 |
| Molecular Weight | 504.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 6 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Levosimendan Impurity 59 (CAS CATO-C4X-130859)
- Baloxavir Impurity 11 (CAS 3047100-03-5)
- Oxazepam impurity 01 (CAS 5504-71-2)
- Nicotinamide guanine dinucleotide sodium salt (CAS 5624-35-1)
- 3-Veratryl-4-Hexanone (CAS 6955-41-5)
- N,N'-((azanediylbis(methylene))bis(3,1-phenylene))diacetamide (CAS 866155-44-4)
- 4-Fluoro-1H-pyrrolo[2,3-c]pyridin-2(3H)-one (CAS 1190310-68-9)
- (2-(Benzyloxy)-4-cyanophenyl)boronic acid (CAS 1884477-63-7)
- 1-{7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl}methanamine (CAS 1020033-70-8)
- Semaglutide impurity 205 (CAS CATO-C4X-2226205)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com