Cefaclor Impurity 37 CAS 21746-02-1
| CAS No. | 21746-02-1 |
| Molecular Formula | C10H10N2O2 |
| Molecular Weight | 190.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cefaclor Impurity 37.
As a process- or degradation-related impurity, Cefaclor Impurity 37 (CAS 21746-02-1, C10H10N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Cefaclor Impurity 37 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 190.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Cefaclor Impurity 37 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H10N2O2 |
| Molecular Weight | 190.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 2 |
Related Cefaclor Standards
- Cefaclor Impurity 57 (CAS CATO-C4X-127057)
- Cefaclor Degradation A Impurity(H-D-Phg-Gly-OH) (CAS 6453-64-1)
- Cefaclor Impurity 46 (CAS 134624-91-2&6453-64-1 (mixture))
- Cefaclor EP Impurity F (CAS 2882-18-0)
- Cefaclor Impurity 11 (CAS 51795-31-4)
- Cefaclor EP Impurity A (CAS 875-74-1)
- Cefaclor Impurity 9 (CAS 6485-67-2)
- Cefaclor Impurity 62 (CAS CATO-C4X-127062)
Recommended Standards
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- Clofarabine Impurity 16 (CAS CATO-C4X-159316)
- Lubiprostone Impurity 25 (CAS CATO-C4X-113625)
- Etrasimod Impurity 46 (CAS CATO-C4X-321446)
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- 3-Bromo-2-(ethylamino)-9H-fluoren-9-one (CAS 5416-85-3)
- 1-(Bicyclo[1.1.1]Pentan-1-yl)-2,2-dimethylpropan-1-ol (CAS 117633-09-7)
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- (R)-tert-Butyl 3-((6-(diethylamino)pyrimidin-4-yl)amino)pyrrolidine-1-carboxylate (CAS 1354000-17-1)
- Des-Ala35-Tirzepatide (CAS CATO-CPTD788939)
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