Propofol Impurity 20 CAS 2178-51-0
| CAS No. | 2178-51-0 |
| Molecular Formula | C24H32O2 |
| Molecular Weight | 352.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 352.51 g/mol gives Propofol Impurity 20 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Propofol Impurity 20 (CAS 2178-51-0) is a certified pharmaceutical impurity reference standard with the molecular formula C24H32O2 and a molecular weight of 352.51 g/mol.
The molecular framework of Propofol Impurity 20 (C24H32O2) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Propofol Impurity 20 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H32O2 |
| Molecular Weight | 352.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Propofol Standards
- Propofol β-D-Glucuronide (CAS 114991-26-3)
- Propofol EP Impurity E (CAS 2416-95-7)
- Propofol Impurity 44 (CAS 83420-68-2)
- Propofol Impurity 28 (CAS 40388-51-0)
- Propofol Impurity 43 (CAS CATO-C4X-147343)
- Propofol Impurity 51 (CAS CATO-C4X-147351)
- Propofol Impuirity 45 (CAS CATO-C4X-147345)
- Propofol impurity 63 (CAS 110398-11-3)
Recommended Standards
- 77-08-7 1,1'-Spirobi(indan)-5,5',6,6'-tetrol, 3,3,3',3'-tetramethyl- (8CI) 1,1'-Spirobi(1H-indene)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 1,1'-Spirobi(1H-inden)-5,5',6,6'-tetrol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- 2,2',3,3'-Tetrahydro-3,3,3',3'-tetramethyl-1,1'-spirobi(1H-indene)-5,5',6,6'-tetrol AI3-16787 EINECS 201-003-1 NSC 512922 1,1'-Spirobi(indane-5,6-diol), 3,3,3',3'-tetramethyl- TTS 5 AI 3-16787 (CAS 77-08-7)
- Monolinolenin (CAS 26545-75-5)
- 67385-10-8 [2-(2-tert-Butoxycarbonylamino-ethyldisulfanyl)-ethyl]-carbamic acid tert-butyl ester di-tert-butyl (disulfanediylbis(ethane-2,1-diyl))dicarbamate (CAS 67385-10-8)
- 1-Monolinolenin (CAS 18465-99-1)
- Benidipine Impurity 71 (CAS CATO-C4X-112071)
- Nicardipine Impurity N4 (CAS 69441-29-8)
- Apixaban Impurity 66 (CAS CATO-C4X-108866)
- Ipenoxazone (CAS 104454-71-9)
- 2-Fluoro-3-(methylthio)phenol (CAS 1243283-09-1)
- Procumbide (CAS 20486-27-5)
- 1-Amino-1-phenylpropan-2-one hydrochloride (CAS 3904-16-3)
- Cabotegravir Impurity 22 (CAS 2883234-38-4)
- 7,8-dihydro-6H-isoquinolin-5-one (CAS 21917-86-2)
- Semaglutide Sodium Salt (CAS CATO-C4X-222620)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com