Atropine EP Impurity G ((R)-Isomer) ((R)-(-)-Littorine) HCl CAS 21956-47-8(free base)

Purity >90%In StockPharmacopoeial Impurity Standards
CAS No.21956-47-8(free base)
Molecular FormulaC17H23NO3
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Atropine EP Impurity G ((R)-Isomer) ((R)-(-)-Littorine) HCl CAS 21956-47-8(free base) chemical structure

Description

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

CATO supplies Atropine EP Impurity G ((R)-Isomer) ((R)-(-)-Littorine) HCl (CAS 21956-47-8(free base)), a pharmacopoeial impurity reference standard (molecular formula C17H23NO3HCl, MW 325.83 g/mol) used for the identification and quantification of trace impurities in APIs.

The molecular framework of Atropine EP Impurity G ((R)-Isomer) ((R)-(-)-Littorine) HCl (C17H23NO3HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC17H23NO3 HCl
Molecular Weight325.83 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor)
Purity>90%
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Halogen ContentCl-containing
Nitrogen Atoms1

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