Paclitaxel EP Impurity O CAS 219783-77-4
| CAS No. | 219783-77-4 |
| Molecular Formula | C49H53NO14 |
| Molecular Weight | 879.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Paclitaxel EP Impurity O is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Paclitaxel EP Impurity O (CAS 219783-77-4, C49H53NO14) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Paclitaxel EP Impurity O (C49H53NO14) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 24.0, corresponding to approximately 24 ring(s) or double-bond equivalent(s). With a molecular weight of 879.94 g/mol, it falls into the high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C49H53NO14 |
| Molecular Weight | 879.94 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 24.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2019 |
| Nitrogen Atoms | 1 |
Related Paclitaxel Standards
- Paclitaxel Impurity 57 (CAS 1053697-17-8)
- Paclitaxel EP Impurity M (CAS 932042-85-8)
- Paclitaxel EP Impurity P (CAS 173101-56-9)
- Paclitaxel EP Impurity J (CAS 2757197-26-3)
- Paclitaxel EP Impurity L (CAS 92950-39-5)
- Paclitaxel EP Impurity F (CAS 153083-53-5)
- Paclitaxel 13C [~1.0Mg/Ml](P) (In Solution) (CAS 379688-61-6)
- Paclitaxel-d5 (CAS 1129540-33-5)
Recommended Standards
- (2R,3R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(3-(2,4-dimethoxybenzyl)-5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl 4-nitrobenzenesulfonate (CAS 290371-75-4)
- SDC-TRAP 0063 (CAS 1472614-83-7)
- Boromycin (CAS 34524-20-4)
- trans-Iodo(p-nitrophenyl)bis(triphenylphosphine)palladium (CAS 33377-47-8)
- Daptomycin impurity 53 (CAS CATO-C4X-137853)
- Erythromycin EP Impurity L (CAS 127955-44-6)
- Azilsartan impurity 149 (CAS CATO-C4X-1096149)
- 4-((3-Chloro-4-fluorobenzyl)oxy)benzaldehyde (CAS 1443345-69-4)
- N-(5-(Benzylthio)-1,3,4-thiadiazol-2-yl)-3-chlorobenzamide (CAS 393566-47-7)
- 3-((3-Fluorophenyl)amino)-2-(naphthalen-1-yl)-1H-inden-1-one (CAS 1024474-09-6)
- Methyl 1-(4-fluorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylate (CAS 1007073-76-8)
- 2-Nonylbenzimidazole (CAS 5851-50-3)
- N,O-Dibenzoyl-L-tyrosine (CAS 14325-35-0)
- Peptide Impurity 70 TFA Salt (CAS CATO-CPTD788570)
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