Paclitaxel EP Impurity J CAS 2757197-26-3
| CAS No. | 2757197-26-3 |
| Molecular Formula | C49H53NO15 |
| Molecular Weight | 895.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Paclitaxel EP Impurity J meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Paclitaxel EP Impurity J (CAS 2757197-26-3, C49H53NO15) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Paclitaxel EP Impurity J (C49H53NO15) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C49H53NO15 |
| Molecular Weight | 895.94 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 24.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Nitrogen Atoms | 1 |
Related Paclitaxel Standards
- Paclitaxel EP Impurity L (CAS 92950-39-5)
- Paclitaxel Impurity 57 (CAS 1053697-17-8)
- Paclitaxel EP Impurity O (CAS 219783-77-4)
- Paclitaxel EP Impurity M (CAS 932042-85-8)
- Paclitaxel EP Impurity P (CAS 173101-56-9)
- Paclitaxel EP Impurity F (CAS 153083-53-5)
- Paclitaxel 13C [~1.0Mg/Ml](P) (In Solution) (CAS 379688-61-6)
- Paclitaxel-d5 (CAS 1129540-33-5)
Recommended Standards
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- 10-Acetoacetyl Paclitaxel (CAS CATO-C4X-184255)
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- 3,3′-(1,2-Ethynediyl)bis[5-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)pyridine] (CAS 1254929-22-0)
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