Tadalafil Impurity 88 CAS 22032-65-1
| CAS No. | 22032-65-1 |
| Molecular Formula | C12H14N2O2 |
| Molecular Weight | 218.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tadalafil Impurity 88 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Tadalafil Impurity 88 (CAS 22032-65-1), a pharmacopoeial impurity reference standard (molecular formula C12H14N2O2, MW 218.25 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Tadalafil Impurity 88 (C12H14N2O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H14N2O2 |
| Molecular Weight | 218.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 2 |
Related Tadalafil Standards
- Tadalafil Impurity 36 (CAS 4299-70-1)
- Tadalafil Impurity 49 (CAS 1379883-12-1)
- Tadalafil Impurity 161 (CAS CATO-C4X-1087161)
- Tadalafil Impurity 117 (CAS CATO-C4X-1087117)
- Tadalafil Impurity 119 (CAS CATO-C4X-1087119)
- Tadalafil Impurity N27 (CAS 21753-16-2)
- Tadalafil Impurity 163 (CAS CATO-C4X-1087163)
- Tadalafil Impurity 164 (CAS 58979-02-5)
Recommended Standards
- Agomelatine Impurity 10 (CAS 20176-04-9)
- Methyl (R)-3-amino-2-((tert-butoxycarbonyl)amino)propanoate Oxalate (CAS 130622-06-9)
- Agomelatine Impurity 34 (CAS 27533-69-3)
- Di-tert-butyl dicarbonate (CAS 24424-99-5)
- Ticagrelor impurity 25 (CAS CATO-C4X-109325)
- Ornidazole Impurity 37 (CAS 28559-13-9)
- Dapagliflozin Impurity 155 (CAS CATO-C4X-1138155)
- 1-(2-Chloro-6-fluorophenyl)propan-2-ol (CAS 1175301-21-9)
- Abemaciclib Impurity 150 (CAS CATO-C4X-2937150)
- 5-Chloro-3-isopropyl-1H-indole (CAS 1441421-47-1)
- 5,6-Diaminopyrimidine-4-carbonitrile (CAS 1208986-24-6)
- 5-bromo-2-methoxy-6-methylpyridine-3-carbonitrile (CAS 88818-88-6)
- 5-(1-Propylpiperidin-2-yl)-1H-indole (CAS 1355178-21-0)
- Semaglutide Impurity 9 (CAS CATO-C4X-22269)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com