Palbociclib Impurity 195 CAS 3060653-14-4
| CAS No. | 3060653-14-4 |
| Molecular Formula | C27H34N8O4 |
| Molecular Weight | 534.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Palbociclib Impurity 195 (CAS 3060653-14-4) is a certified pharmaceutical impurity reference standard with the molecular formula C27H34N8O4 and a molecular weight of 534.61 g/mol.
The molecular framework of Palbociclib Impurity 195 (C27H34N8O4) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Palbociclib Impurity 195 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H34N8O4 |
| Molecular Weight | 534.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Nitrogen Atoms | 8 |
Related Palbociclib Standards
- Palbociclib Impurity 16 (CAS CATO-C4X-112516)
- Palbociclib Impurity 76 (CAS 1941177-45-2)
- Palbociclib Impurity 200 (CAS 2204368-69-2)
- Palbociclib Impurity 40 (CAS CATO-C4X-112540)
- Palbociclib Sulfamic Acid (CAS CATO-C4X-112536)
- Palbociclib Impurity 89 (CAS 1974279-21-4)
- Palbociclib Impurity 33 (CAS 1651214-74-2)
- Palbociclib Impurity 196 (CAS 3066072-08-7)
Recommended Standards
- 3-((1H-Benzo[d]imidazol-2-yl)amino)-4-(((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione (CAS 2565792-36-9)
- Ilaprazole Impurity 96 (CAS CATO-C4X-113096)
- (2R,4R)-1-[(2S)-2-[(tert-Butyloxycarbonyl)amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic Acid Benzyl Ester (CAS 367952-82-7)
- Biotinyl-AEEAc-AEEAc-OH (G-4740.0050) (CAS 1301706-65-9)
- Melitracen Impurity 7 (CAS 42332-94-5)
- Dapagliflozin Impurity 141 (CAS 1629862-21-0)
- Phentolamine Impurity 16 (CAS CATO-C4X-224716)
- 5-Bromo-2-(trifluoromethoxy)cinnamic acid (CAS 1381952-88-0)
- 5-Bromo-3-(4-chlorophenyl)isoxazole (CAS 51725-92-9)
- Oxo Thiamine O-Diphosphate (CAS 59733-97-0)
- Pyrazolo[1,5-a]pyrazine-7-carbonitrile, 4,5,6,7-tetrahydro-5-(phenylmethyl)- (CAS 2148334-10-3)
- 3,3,3',3'-Tetramethyl-5,5',6,6'-tetrapropoxy-2,2',3,3'-tetrahydro-1,1'-spirobi[indene] (CAS 89929-65-7)
- 3-Quinolinecarbonitrile, 2-ethyl- (CAS 41969-16-8)
- [γ-Glu]15 Semaglutide (CAS CATO-C4X-222690)
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