Palbociclib Impurity N87 CAS 2205035-04-5
| CAS No. | 2205035-04-5 |
| Molecular Formula | C24H29N7O2 |
| Molecular Weight | 447.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Palbociclib Impurity N87.
Palbociclib Impurity N87 (CAS 2205035-04-5) is a certified pharmaceutical impurity reference standard with the molecular formula C24H29N7O2 and a molecular weight of 447.53 g/mol.
The molecular framework of Palbociclib Impurity N87 (C24H29N7O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H29N7O2 |
| Molecular Weight | 447.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 7 |
Related Palbociclib Standards
- Palbociclib (CAS 571190-30-2)
- Palbociclib Impurity 11 (CAS CATO-C4X-112511)
- Palbociclib Impurity 157 (CAS CATO-C4X-1125157)
- Palbociclib Impurity 159 (CAS 2204368-66-9)
- Palbociclib Impurity 41 (CAS CATO-C4X-112541)
- Palbociclib Impurity 7 (CAS CATO-C3D-1456)
- Palbociclib Impurity 20 (CAS CATO-C3D-1542)
- Palbociclib Impurity 22 (CAS 1376615-91-6)
Recommended Standards
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- Olmesartan Impurity 55 (CAS 1227626-44-9)
- 1-(4-Amino-5-methoxypyridin-3-yl)ethan-1-one (CAS 1393573-60-8)
- Ethyl 5,5-difluoro-2-oxocycloheptane-1-carboxylate (CAS 2375930-27-9)
- 5-Chloromethyl-pyridin-2-ol HCl (CAS 1227574-78-8（free base）)
- 1-(1,1-Difluoro-2,3-dihydro-1H-inden-4-yl)ethan-1-one (CAS 1779810-61-5)
- Integerrimine (CAS 480-79-5)
- 2-(2-Methyl-1-(4-(methylsulfonyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid (CAS 872365-16-7)
- ([D?]Val?·1?)-C-Peptide (human) (CAS 1802078-41-6)
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