Darolutamide Impurity 24 CAS 2222114-43-2
| CAS No. | 2222114-43-2 |
| Molecular Formula | C18H21ClN4O2 |
| Molecular Weight | 360.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Darolutamide Impurity 24 (CAS 2222114-43-2) is a certified pharmaceutical impurity reference standard with the molecular formula C18H21ClN4O2 and a molecular weight of 360.84 g/mol.
Based on its molecular formula C18H21ClN4O2, Darolutamide Impurity 24 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 360.84 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H21ClN4O2 |
| Molecular Weight | 360.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Darolutamide Standards
- Darolutamide Impurity 12 (CAS 2415967-06-3)
- Darolutamide Impurity 33 (CAS CATO-C4X-310633)
- Darolutamide Impurity 26 (CAS CATO-C4X-310626)
- Darolutamide Impurity 38 (CAS CATO-C4X-310638)
- Darolutamide Impurity 44 (CAS CATO-C4X-310644)
- Darolutamide Impurity 43 (CAS CATO-C4X-310643)
- Darolutamide Impurity 25 (CAS CATO-C4X-310625)
- Darolutamide Impurity 27 (CAS 1297538-27-2)
Recommended Standards
- 1-[(4-chlorophenyl)methyl]-N-phenyl-1H-indole-3-carboxamide 10T-1490 860611-50-3 (CAS 860611-50-3)
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- N-Benzyl-5-chloro-3-phenyl-2H-isoindole-1-carboxamide (CAS 61295-36-1)
- Xipamide-d6 (CAS 1330262-09-3)
- Sivelestat sodium Impurity 3 (CAS 155023-59-9)
- Lusutrombopag Impurity 24 (CAS CATO-C4X-208424)
- Vazegepant Impurity 19 (CAS 2923756-41-4)
- Orobanchyl Acetate (CAS 1413843-71-6)
- N-(4-Fluorophenyl)hydrazinecarbothioamide (CAS 330-94-9)
- (3R)-3-methyl-1-(oxan-4-yl)piperazine (CAS 1187931-25-4)
- 2-((1-(Prop-2-yn-1-yl)-1H-indol-3-yl)thio)acetonitrile (CAS 61021-46-3)
- 5-Phenyl-2,4’-bipyridine (CAS 340026-72-4)
- 1-Cyclopropyl-1-(3-fluoro-4-methoxyphenyl)ethan-1-ol (CAS 1202774-76-2)
- Acetyl Tetrapeptide-5 (CAS 820959-17-9)
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