Roxadustat Impurity 66 CAS 2222121-34-6
| CAS No. | 2222121-34-6 |
| Molecular Formula | C24H25NO5 |
| Molecular Weight | 407.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Roxadustat Impurity 66 (CAS 2222121-34-6, C24H25NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Roxadustat Impurity 66 (C24H25NO5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures Roxadustat Impurity 66 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H25NO5 |
| Molecular Weight | 407.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 1 |
Related Roxadustat Standards
- Roxadustat Impurity 169 (CAS 2731734-01-1)
- Roxadustat Impurity 88 (CAS CATO-C4X-221388)
- Roxadustat Impurity 13 (CAS CATO-C4X-221313)
- Roxadustat Impurity 147 (CAS CATO-C4X-2213147)
- Roxadustat impurity 114 (CAS CATO-C4X-2213114)
- Roxadustat Impurity 175 (CAS CATO-C4X-2213175)
- Roxadustat Impurity 3 (CAS CATO-C4X-22133)
- Roxadustat Impurity 87 (CAS 1537180-08-7)
Recommended Standards
- Finerenone Impurity 122 (CAS CATO-C4X-2880122)
- Galanthamine Impurity 28 (CAS CATO-C4X-143528)
- Finerenone Impurity 148 (CAS CATO-C4X-2880148)
- 4-Methyl Erlotinib (CAS 1346601-52-2)
- Cyclobenzaprine Impurity 4 (CAS 1971-54-6)
- Umeclidinium Impurity 4 (CAS 869112-31-2)
- Esomeprazole Impurity 123 (CAS 784143-42-6/89352-76-1)
- 6-Chloro-2-(difluoromethyl)-5-nitropyridin-3-ol (CAS 1805386-28-0)
- N-(6-Sulfanylpyridazin-3-yl)thiophene-2-carboxamide (CAS 1286700-26-2)
- 1-(3,5-Dibromothiophen-2-yl)ethan-1-one (CAS 80775-52-6)
- Dorzolamide Impurity 7 (CAS CATO-C4X-12287)
- N-(5-Methyl-[1,3,4]thiadiazol-2-yl)-2-m-tolylamino-propionamide (CAS 1008996-27-7)
- 2-(5-(4,5-Diamino-2-fluoro-3-(tetrahydrofuran-2-yl)phenyl)pyrimidin-2-yl)propan-2-ol (CAS 1384984-29-5)
- D-Ala18-Tirzepatide (CAS CATO-CPTD788916)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com