Lemborexant Impurity 80 CAS 2227744-56-9
| CAS No. | 2227744-56-9 |
| Molecular Formula | C11H9FO4 |
| Molecular Weight | 224.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Lemborexant Impurity 80 (CAS 2227744-56-9), a pharmacopoeial impurity reference standard (molecular formula C11H9FO4, MW 224.19 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Lemborexant Impurity 80 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 224.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H9FO4 |
| Molecular Weight | 224.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
Related Lemborexant Standards
- Lemborexant Impurity 99 (CAS CATO-C4X-304299)
- Lemborexant impurity 18 (CAS CATO-C4X-304218)
- Lemborexant Impurity 68 (CAS CATO-C4X-304268)
- Lemborexant Impurity 97 (CAS CATO-C4X-304297)
- Lemborexant Impurity 65 (CAS 3070371-35-3)
- Lemborexant Impurity 66 (CAS 1450905-00-6)
- Lemborexant Impurity 95 (CAS 3070371-42-2)
- Lemborexant impurity 01 (CAS 1369768-29-5)
Recommended Standards
- Cyclophosphamide Impurity 5 (CAS 90632-33-0)
- Triethyl Phosphonoacetate (CAS 867-13-0)
- Cyclophosphamide Impurity 15 (CAS CATO-C4X-230615)
- Ethyl 5-(trifluoromethyl)thiophene-2-carboxylate (CAS 1141011-56-4)
- Bumetanide EP Impurity C (CAS 32643-00-8)
- Lurbinectedin Impurity 6 (CAS 3054883-63-2)
- Pomalidomide Impurity 25 (CAS CATO-C4X-135425)
- 1-Methylpiperidin-3-yl acetate (CAS 6659-33-2)
- 1-Propylpiperidin-4-ol (CAS 105409-83-4)
- 3-Chloro-5-methoxy-2-methylpyridine (CAS 1227593-87-4)
- 1-(4-Fluorophenyl)-4-methoxy-1h-pyrazole-3-carboxylic acid (CAS 1169973-47-0)
- Cyclobutane-1,2-diyldimethanamine (CAS 3396-16-5)
- Trazodone Impurity 60 HCl (CAS 220910-13-4)
- Neuropeptide EI (human, mouse, rat) (CAS 125934-45-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com