Afatinib Impurity 47 CAS CATO-C4X-100647
| CAS No. | CATO-C4X-100647 |
| Molecular Formula | C24H24ClFN6O4 |
| Molecular Weight | 514.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Afatinib Impurity 47 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 514.94 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Afatinib Impurity 47 (CAS CATO-C4X-100647), a pharmacopoeial impurity reference standard (molecular formula C24H24ClFN6O4, MW 514.94 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Afatinib Impurity 47 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H24ClFN6O4 |
| Molecular Weight | 514.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related Afatinib Standards
- Afatinib Impurity 33 (CAS CATO-C4X-100633)
- Afatinib Impurity 8 (CAS CATO-C4X-10068)
- Afatinib Impurity 48 (CAS 3005278-77-0)
- Afatinib dichloro impurity (CAS 2223677-63-0)
- Afatinib Impurity 4 (CAS CATO-C4X-10064)
- Afatinib Impurity 11 (CAS CATO-C4X-100611)
- Afatinib Impurity 57 (CAS CATO-C4X-100657)
- Afatinib Impurity 87 (CAS CATO-C4X-100687)
Recommended Standards
- Calcitriol Impurity 12 (CAS CATO-C4X-151012)
- 3,3′′′-dihexyl-2,2′:5′,2′′:5′′,2′′′-tetrathiophene (CAS 132814-91-6)
- Alfacalcidol Impurity 23 (CAS CATO-C4X-139323)
- Tris(3-bromophenyl)phosphine Oxide (CAS 38019-09-9)
- Roxadustat Impurity 124 (CAS CATO-C4X-2213124)
- Caspofungin EP Impurity B Acetate(RRT=1.50) (CAS 314080-31-4 (free base))
- Dabigatran Impurity 33 (CAS CATO-C4X-108933)
- 2-Chloro-4-ethoxybenzenesulfonyl chloride (CAS 1016729-08-0)
- 2'-Methoxy[1,1'-biphenyl]-3-carbonitrile (CAS 154848-37-0)
- 2-(4-Chloro-5-methyl-1H-pyrazol-1-yl)propan-1-amine (CAS 1170856-32-2)
- 5-Hydroxy-7-(o-tolyl)benzo[d][1,3]oxathiol-2-one (CAS 1353501-83-3)
- 3-(7-Hydroxy-4,8-dimethyl-2-oxo-2H-chromen-3-yl)propanoic acid (CAS 500204-30-8)
- 5-(5-Methoxybenzo[b]thiophen-2-yl)-1H-pyrrole-2-carboxylic acid (CAS 1889802-11-2)
- Neuropeptide EI (human, mouse, rat) (CAS 125934-45-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com