Febuxostat Impurity 53 CAS 2230270-05-8
| CAS No. | 2230270-05-8 |
| Molecular Formula | C18H20N2O3S |
| Molecular Weight | 344.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Febuxostat Impurity 53 (CAS 2230270-05-8, C18H20N2O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, Febuxostat Impurity 53 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 344.43 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H20N2O3S |
| Molecular Weight | 344.43 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Febuxostat Standards
- Febuxostat Impurity 13 (CAS 160844-75-7)
- Febuxostat Impurity 54 (CAS 2375033-35-3)
- Febuxostat Impurity 55 (CAS CATO-C4X-116255)
- Febuxostat impurity 91 (CAS 1380049-42-2)
- Febuxostat Impurity 99 (CAS CATO-C4X-116299)
- Febuxostat Impurity 43 (CAS 161798-03-4)
- Febuxostat Impurity 60 (CAS 2230270-03-6)
- Febuxostat Impurity 81 (CAS 2375033-31-9)
Recommended Standards
- Amisulpride Impurity 56 (CAS CATO-C4X-104556)
- Amisulpride Impurity 33 (CAS CATO-C4X-104533)
- Cefazedone Impurity 11 (CAS CATO-C4X-117111)
- Tert-butyl 4-(5-cyanobenzo[d]thiazol-2-yl)piperazine-1-carboxylate (CAS 2231676-60-9)
- Canagliflozin Impurity 42 (CAS CATO-C4X-112342)
- Cholecalciferol EP Impurity E (CAS 17592-07-3)
- Cyclophosphamide Impurity 4 (CAS 2810251-24-0)
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- 1-(3-methyloxetan-3-yl)propan-1-ol (CAS 2092509-38-9)
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- 2-(2-(5-Bromofuran-2-yl)-6-chloroimidazo[1,2-a]pyridin-3-yl)acetic acid (CAS 88623-38-5)
- 2-(Difluoromethyl)-3-iodo-5-methoxypyridine-6-methanol (CAS 1805530-99-7)
- Semaglutide Sodium Salt (CAS CATO-C4X-222620)
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