Mometasone Furoate EP Impurity B CAS 223776-49-6
| CAS No. | 223776-49-6 |
| Molecular Formula | C28H31ClO8S |
| Molecular Weight | 563.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Mometasone Furoate EP Impurity B.
CATO supplies Mometasone Furoate EP Impurity B (CAS 223776-49-6), a pharmacopoeial impurity reference standard (molecular formula C28H31ClO8S, MW 563.06 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Mometasone Furoate EP Impurity B (C28H31ClO8S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H31ClO8S |
| Molecular Weight | 563.06 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Mometasone Standards
- Mometasone Furoate EP Impurity T (CAS CATO-C4X-170420)
- Mometasone Impurity 38 (CAS CATO-C4X-170438)
- Mometasone Impurity 32 (CAS CATO-C4X-170432)
- Mometasone Impurity 43 (CAS CATO-C4X-170443)
- Mometasone Furoate EP Impurity R (CAS 1370190-08-1)
- Mometasone Furoate Impurity 23 (CAS 83897-05-6)
- Mometasone Furoate EP Impurity I (CAS CATO-C4X-170410)
- Mometasone RC 2 (CAS 83880-62-0)
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Why CATO?
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