Mometasone Furoate EP Impurity R CAS 1370190-08-1
| CAS No. | 1370190-08-1 |
| Molecular Formula | C28H33ClO9S |
| Molecular Weight | 581.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Mometasone Furoate EP Impurity R (CAS 1370190-08-1, C28H33ClO9S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Mometasone Furoate EP Impurity R (C28H33ClO9S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 581.07 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H33ClO9S |
| Molecular Weight | 581.07 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Mometasone Standards
- Mometasone Furoate EP Impurity I (CAS CATO-C4X-170410)
- Mometasone Impurity 43 (CAS CATO-C4X-170443)
- Mometasone Impurity 32 (CAS CATO-C4X-170432)
- Mometasone Furoate EP Impurity B (CAS 223776-49-6)
- Mometasone Furoate EP Impurity T (CAS CATO-C4X-170420)
- Mometasone Impurity 38 (CAS CATO-C4X-170438)
- Mometasone Impurity 44 (CAS CATO-C4X-170444)
- Mometasone Furoate EP Impurity E (CAS 1370190-33-2)
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